www.alphalabs.co.uk 3 BÜHLMANN calprotectin assays are standardised between formats, so from point of care to high throughput laboratory testing, results are consistent. Find out more about the full range of calprotectin assays and read user case studies at www.calprotectin.co.uk Figure 1. Faecal Calprotectin Algorithm Red Flag Indicators ï Unintentional weight loss ï Rectal bleeding ï Family history of bowel/ovarian cancer ï Anaemia ï Abdominal/rectal mass ï Nocturnal symptoms ï Raised inflammatory markers ï Bloody diarrhoea ï Systemically unwell Symptoms of IBD or IBS Age 18 - 60 with diagnostic uncertainty ï If cancer suspected: 2 week cancer referral ï If acute severe IBD suspected then urgent IBD referral Yes No Primary diagnostic: FBC, CRP coeliac screen, stool MCS, U&E, Bone profile, TFT Negative Positive Treat as appropriate Faecal calprotectin (FC) FC<100 FC 100-250 FC>250 Clinical Review Repeat within 2 weeks IBD unlikely FC<100 FC 100-250 FC>250 Manage symptoms locally Symptoms persist FC <50 AND age <50 consider second line therapy for IBS before referral FC >50 or age >50 Routine referral to gastroenterology Urgent referral to gastroenterology
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