The BÜHLMANN sCAL turbo, compatible with mainstream clinical chemistry analysers such as Roche, Beckman, and Abbott, boasts a swift time to the first result at 10 minutes, with subsequent results available every few seconds thereafter, contingent on the analyser’s cycle time. Initial results on the Vitros analyser are promising, displaying the anticipated linearity and precision (see Figure 1), and comparisons with results from the Mindray BS480 at BÜHLMANN have been conducted (see Figure 2). While the lab has undertaken preliminary sample comparisons between the ELISA and sCAL turbo methods, further investigations are scheduled for the upcoming year to establish appropriate cut-offs for the new standardisation. References: 1. Leading Edge Summer 2016 - on request from Alpha Laboratories 2. Moncrieffe H, et al. A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein. Rheumatology (Oxford). 2013 Aug;52(8):1467-76. BÜHLMANN sCAL turbo Performance Figure 1: Linearity Serum Calprotectin in the Inflammatory Response When calprotectin is released from white cells, it initiates a strong inflammatory response and rapidly forms a tetrameric format in conjunction with metal ions (calcium, zinc, magnesium). There is as much calprotectin in white cells as there is haemoglobin in red cells, accounting for around 60% of the soluble protein content. In conditions which provoke an inflammatory response the level of calprotectin in the blood can increase significantly. Although it is a non-specific marker, it can be used to aide diagnosis and determine the severity of certain conditions in conjunction with the other clinical evidence. The diagnostic advantage of calprotectin detection over other disease markers is that it is stored in the cell and released immediately in response to local situations. In contrast, other markers may be released by downstream pathways or need to be synthesised leading to delays in detection. If you would like more information on serum calprotectin testing from BÜHLMANN (lateral flow POC, laboratory ELISA or the new sCAL® turbo assay) then please visit the website: www.alphalabs.co.uk/serum-calprotectin or ask your local Key Account Manager for more information. Figure 2 : Ortho Vitros V the Mindray BS480 www.alphalabs.co.uk © 2024 Copyright Alpha Laboratories Ltd. 7
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