Leading Edge 2024 Issue 1

Experience the Next Level CALEX® Workflow Revolution Amanda Appleton, Senior Product Manager, Alpha Laboratories Ltd. In 2014, the CALEX Cap transformed faecal calprotectin extraction workflows in laboratories. Now, with CALEX faecal calprotectin collection kits, patients can prepare and return their own samples, eliminating the need for traditional stool samples. The lab receives a ready-to-use CALEX, streamlining the testing process. This revolutionary shift maximises laboratory resources, reshaping calprotectin testing workflows significantly. CALEX Cap is suitable for air and land transportation according to IATA 650 (UN3373) regulations. This allows the option to outsource pre-analytics to the patient’s home, increasing safety for laboratories and revolutionising speed, efficiency and cost savings in the stool testing workflow. With the CALEX Faecal Calprotectin Collection Kit it is possible to keep stool samples away from the laboratory and measure faecal calprotectin and Pancreatic elastase from ready-touse extracts using the high quality BÜHLMANN assays. Patient Friendly Kits Each kit is discretely packaged in a business style envelope with a CALEX extraction device with patient specific instructions for use leaflet (IFU) and an integral label (name, DOB and sample collection date). A clear grip seal bag is also included, for return of the CALEX and the request form back to the laboratory or GP. The IFU is written in lay terms and has guidance on taking the sample, simple to follow instructions with diagrams, and a link to a video to support the correct usage of the CALEX with different sample consistencies. The kits come in boxes of 20 and are stored at ambient temperature. Shelf life on receipt is generally 12 – 18 months, so that kits can be sent out to clinics and primary care in quantities, and conditions, that will minimise wastage. The boxes have a dispensing tally on the front to help maintain the correct level of stock within individual locations. Hospitals can order the kits through Alpha Laboratories and send them to clinics and primary care using their existing van delivery/sample collection services. Alternatively, the boxes of kits can be sent directly to individual locations using The Alpha Portal – A new ordering and stock control platform from Alpha Laboratories. Sample Stability Calprotectin Stability One of the biggest issues with calprotectin testing is the variable rates of degradation that occur within the stool sample. This was demonstrated in a stability study1, showing individual samples to have significantly different rates of degradation. The overall conclusion from this publication, and the widely accepted premise, is that calprotectin is stable at ambient in a stool sample for three days. Within the data, however, whilst some samples are relatively stable, others lose between 30 – 50% of detectable calprotectin in that time period. 2 Leading Edge