Leading Edge 2022 Issue 2

www.alphalabs.co.uk 3 However, when we started, we loaded the CALEX into special false bottom racks. This means we can specify the lower limit of liquid detection for the sample probe to avoid contact with the preparation stick within the CALEX tube. We just front load the racks onto the Atellica sample handler in a rack on rack off system – it really is very straight forward and there have been no issues. At the moment we don’t have the auto-dilute to report up to 8000µg/g switched on because we would need to keep the samples on the analyser for longer. We know the autodilute function works as we have tested it, but from a workflow perspective it is better that it is not activated. The use of an upper limit of 1500ug/g for reporting has not been raised as a concern by Clinicians. The verification took place over a period of one month. We didn’t plan to go live straight away so we continued the routine work on the Advia analysers until things were completely ready. Go Live We went live with the calprotectins on the Atellica at the end of June this year, once we had completed our validation work. We have now been running for 4 months, and everything has gone as smoothly as we could have hoped. Really it has been very quick and easy. We batch the samples and run them twice a week which is what we have always done, so the service provision is still the same. So far we have run over 10,000 samples and there have been absolutely no issues. EQA We have now returned results for 3 distributions, results from these have been acceptable and in keeping with our performance on the Advia 2400. Service Security Following our instrument upgrade by Siemens to the Atellica systems our calprotectin service has greater security. Our set-up involves 3 Atellica lines, each with two chemistry and one immunoassay analyser. The Atellica system provides a number of benefits over the Advia system, including real time reagent loading, higher throughput and having multiple chemistry analysers as back-up options if required - I am definitely a fan. Pancreatic Elastase We are currently working on other development projects in the laboratory. Once these are completed we hope to evaluate the BULHMANN fPELA assay for pancreatic assay. This is with the hope that an automated system can improve lab efficiencies in light of an ever growing workload. For more information, visit our website calprotectin.co.uk/fcalturbo Figure 1: 52 patient sample comparison of BÜHLMANN fCAL turbo assays run on the Advia 2400 and the Atellica analysers

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