The latest product news and exclusive offers. 2023 SPECIAL OFFERS • EXCLUSIVE PRODUCTS • QUALITY • VALUE • EXCELLENCE • ONLINE ORDERING • MONEY-BACK GUARANTEE • FAST, FREE DELIVERY An Alpha Laboratories publication A Model To Suit All PCR Needs GeneExplorer™ Thermal Cycler SPECIAL OFFER* SAVE £1000 *Offer for limited time only - more information on page 16. Fine Tip Pastette® Page 12 SPECIAL OFFER SAVE 40% SPECIAL OFFER SAVE 20% Proline® Plus Pipettes Page 8 BUNDLE OFFER ONLY £1900 Preparation for Perfect PCR Performance Page 20 Next Generation Nano Injection Page 14
2 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Welcome to LabVantage Your magazine for exclusive product offers and news brought to you by Alpha Laboratories. We are delighted to bring you the latest issue of LabVantage, a specialist resource tailored exclusively for the scientific community. Our focus is on presenting you with the latest product news and essential offers that cater to your every day lab needs and foster progress in your field. More products and offers can be found on our new website: www.alphalabs.co.uk /current-special-offers Our Commitment to Sustainability: Preserving Our Planet At Alpha Laboratories, we understand the significance of sustainable practices for a better future. As part of our commitment to environmental responsibility, we are dedicated to reducing our environmental footprint and promoting sustainability within the scientific realm. To learn more about our sustainability initiatives and partnerships, we encourage you to explore our dedicated pages: www.alphalabs.co.uk/sustainability. Here, you will find comprehensive information on our efforts to support eco-friendly practices. Thank you for being an integral part of the scientific community. The LabVantage Team Alpha Laboratories, 40 Parham Drive, Eastleigh, Hampshire, SO50 4NU, UK. Tel: 023 8048 3000 sales@alphalabs.co.uk www.alphalabs.co.uk Registered in England 1215816 New Alpha Laboratories’ Website 3 ACT on Climate Change with Fastrak® and FastZAP™ 4-5 Introducing FastZap™ Filter Tip Refills 6 LaboraTree - Now it’s Even Easier to be Green 7 Proline® Plus Pipettes - Save 20% 8-9 Pipette Calibration Services 10-11 Fine Tip Pastette® - Save 40% 12-13 Nanoject III - Next Generation Nano Injection 14-15 Bioer GeneExplorer™ Collection - Save £1000 16-17 The ThermoCell System - Heat, Cool and Mix 18-19 Preparation for Perfect PCR Performance 20-21 Colour-Code Your Lab! 22-23 Multiple Microplates and Sealing Films for All Your Applications 24-25 Support for Exosome Research 26-27 In this issue:
3 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 This year Alpha Laboratories launched a completely new website to support your Diagnostic and Laboratory needs. Designed to offer scientists easier access to a wealth of information, across its supplies, services and solutions it reflects the company’s growth, through its customer-focused approach. The application driven platform is tailored to meet the needs of both new and existing customers. With a modern, user-friendly interface that is easy to navigate the new website features a practical search function with intelligent filtering capabilities that enables users to conveniently browse through both product listings and supplementary information page options. This helps you find exactly what you need easily and quickly, whether you are planning an immediate purchase through the efficient e-commerce platform or are researching options to be ordered through your own internal procurement system. “Our priority has always been to provide the best possible products and services to our customers and our new website is just one of the many ways we continue to support that,” says Carole Staniford, Marketing Director. “We’ve worked hard to create a website that reflects our commitment to our customers, and we believe that our new site will make it easier for them to do business with us, from direct online transactions to working in partnership to create bespoke customer solutions.” The updated design is compatible with all devices and screen sizes, ensuring that users can access the site on the go, and from any platform. Customers can easily search for products by item code, key words, category or applications, view product specifications, access literature, videos etc. and even place orders directly online. The website is live now and ready to explore. Take a look at: www.alphalabs.co.uk Have You Seen Our Brand New Online Experience?
4 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 ACT on Climate Change with Fastrak® and FastZAP™ Pipette Tip Refills to Reduce Your Lab’s Carbon Footprint › Fastest possible racking › BioPolymer base and vegetablebased printing inks › Made using 61% renewable energy (30% onsite Solar Power) › Tips Manufactured from Highest Grade Resins › Excellent Tip-fit Across a Wide Range of Pipettes › Ultrafine Flexible Tips, Bevelled or Non-bevelled Orifice The Greenest Choice... Without Compromise Fastrak® pipette tip refill system excels in all environmental aspects compared to other popular refill systems. It is lighter, smaller and uses less packaging that is almost entirely renewable (95%).
5 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Product Code Product Description Pack Description List Price (excl. VAT) FR0250 1-200µl Universal FlexTop Ultrafine Tip Non-Sterile 50mm in length 10x96 £39.00 FR1010 0.1-10µl TubeGuard Top Ultrafine Tip Extended-Length Non-Sterile 38mm in length 14x96 £48.00 FR1015 0.1-10µl Universal Micro Ultrafine Tip Graduated Non-Sterile 32mm in length 13x96 £45.00 FR1200 1-200µl Universal Bevelled Yellow Non-Sterile 50mm in length 10x96 £25.00 FR1250 100-1250µl FlexTop Ultrafine Tip Extended-Length Non-Sterile 89mm in length 5x96 £23.00 FR1300 1-300µl FlexTop Ultrafine Tip Extended-Length Non-Sterile 71mm in length 6x96 £28.00 FR2200 1-200µl Universal Bevelled Tip Graduated Non-Sterile 50mm in length 10x96 £27.00 FR3000 100-1000µl Rainin® LTS®-Fit Tip Non-Sterile 89mm in length 5x96 £24.00 FR3020 0.1-20µl Rainin® LTS®-Fit Tip Non-Sterile 48mm in length 11x96 £37.00 FR3250 Tip 0.5-250µl Rainin® LTS®-Fit Tip Graduated Non-Sterile 51mm in length 10x96 £35.00 Fastrak® Tip Refill Systems Ordering Information ACT Verification Fastrak will proudly display the ACT eco label that emphasises accountability, consistency, and transparency around manufacturing, user impact, and end-of-life impact. My Green Lab created the ACT Environmental Impact Factor Label to inform users by quantifying how laboratory products rate in sustainability categories including: › Manufacturing impact › Energy use › Packaging waste › Lifetime rating Relevant categories on the ACT Label are rated on a scale of 1–10. The lower the score, the lower the impact on the environment. The sum of the values is the environmental factor. ACT product scores are independently audited by Sustainability Made Simple and verified by My Green Lab. Find out more and buy online at: www.alphalabs.co.uk/fastrak Example label for illustration purposes only.
6 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Now you can reduce your plastic usage when you need a quality aerosol resistant filter tip for your exacting applications. FastZAP™ refills can be used to refill empty pipette tip racks with ZAP™ premier filter tips. Their low carbon footprint makes them an ideal solution to waste reduction goals for your lab. They bring the ease and value of Fastrak® refills to your filter tips. Coming Soon! Introducing FastZAP™ Filter Tip Refills ZAP™ Premier Filter Tips – Now in Eco-friendly Refills Keep an eye out on our new website for more updates: www.alphalabs.co.uk/FastZAP › Packaging made exclusively from recyclable and renewable materials › Simply lift, place and snap into a reusable rack › Quality polypropylene tips with a pure 10μm pore size autoclavable filter › Certified RNase and DNase and endotoxin-free › Validated sterility process
*Correct at time of printing 7 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 We first launched our LaboraTree scheme back in 2011 and since then we’ve planted over 2600 trees in UK woodlands. The LaboraTree scheme awards tokens for each Fastrak® tip refill or ZAP™ Premier filter tip pack that you purchase. More Trees for Your Tips At the end of 2022, we halved the number of tokens needed to plant a tree, meaning you now only need 15 tokens rather than the previous 30, making it even easier to get involved. This means we can now plant twice as many trees, for an even bigger positive impact on our planet, whilst helping you reduce waste in your lab. More Benefits for the Environment and for YOU! Join LaboraTree Now It’s easy to get involved, just contact us to register and we will send you a LaboraTree collector’s card so you can start turning your tips into trees. Have You Heard About LaboraTree? Now it’s Even Easier to be Green For more information about the LaboraTree scheme and to keep up to date with our tree planting totals, visit: www.alphalabs.co.uk/laboratree
8 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Choose Proline® Plus Pipettes Comfort, Quality and Durability in Your Everyday Tasks Ergonomics For effortless pipetting and reduced risk of RSI: › Comfortable handle and ergonomic finger support › Light pipetting forces Optiload tip loading mechanism in multichannel models allows tips to be loaded and ejected with minimum force. Safety › Safe-Cone Filters in all models >10μl minimise risk of contamination › Fully autoclavable without disassembly › Convenient, easy to steam sterilise › Colour-coded push button caps make tip matching quick and easy › Large numbers in volume display minimise errors › Volume setting with click stop › Optiload tip loading mechanism in multichannel models easily secures perfect, even tip sealing Easy Maintenance › Only three parts to disassemble when cleaning – no tool required SPECIAL OFFER SAVE 20% Proline® Plus pipettes are the superior choice for both experienced laboratory professionals and students.
9 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Durability › High chemical and UV resistance performance › Thermal insulation of internal components maintains sampling temperature for highly accurate and repeatable results in long pipetting series › Easy calibration by the user for liquids with various consistencies using the tool provided Product Code Product Description Pack Size List Price (excl. VAT) OFFER Price (excl. VAT) 728010 Single Channel 0.1-3µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728020 Single Channel 0.5-10µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728030 Single Channel 2-20µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728050 Single Channel 10-100µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728060 Single Channel 20-200µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728070 Single Channel 100-1000µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728080 Single Channel 500-5000µl Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728090 Single Channel 1-10ml Variable Volume Proline® Plus Pipette Each £249.48 £199.58 728120 8-Channel 0.5-10µl Variable Volume Proline® Plus Pipette Each £718.20 £574.56 728130 8-Channel 10-100µl Variable Volume Proline® Plus Pipette Each £718.20 £574.56 728140 8-Channel 30-300µl Variable Volume Proline® Plus Pipette Each £718.20 £574.56 728220 12-Channel 0.5-10µl Variable Volume Proline® Plus Pipette Each £794.88 £635.90 728230 12-Channel 10-100µl Variable Volume Proline® Plus Pipette Each £794.88 £635.90 728240 12-Channel 30-300µl Variable Volume Proline® Plus Pipette Each £794.88 £635.90 Order online at www.alphalabs.co.uk/prolineplus or Quote Offer Code LV2301 SPECIAL OFFER SAVE 20% Proline® Plus Pipettes Ordering Information
10 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Your Complete Liquid Handling Solution Alpha Laboratories, a Trusted Liquid Handling Partner of Sartorius, offers comprehensive solutions, including expert service and calibration for liquid handling instruments. Our commitment to enhancing customer experience drives us to deliver end-to-end solutions. Partnering with Sartorius aligns with our dedication to excellent products and top-tier service. With a rising demand for precise laboratory data, ensuring accurate measuring instrument results is crucial. Regular servicing and calibration are essential to maintain precision. This is particularly vital for pipettes, commonly used in various techniques requiring exacting accuracy. Alpha Lab Service utilises the recognised calibration expertise of Sartorius, offering a comprehensive list of services that extends to all manufacturers’ pipettes, providing a single service point. Our options include on-site clinics and a mail-in workshop service On-site Clinics: › Fast turnaround, ideal for daily pipette users › Skilled technicians equipped with cutting-edge calibration tools › Convenient service across the UK Mail-in Workshop Service: › Expert technicians with advanced calibration lab › Proprietary software for reliable results Alpha Laboratories www.alphalabs.co.uk The Complete Liquid Handling Solution Service Training Pipettes Tips
11 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Service Levels Our services cater to various needs with two levels available for single and multichannel, electronic, and mechanical pipettes. All options include functionality testing, thorough inspection, leak testing, cleaning, and detailed service reports. Choosing the Right Level: Trust our experts to guide you. We offer two service levels: 1. Standard Calibration Certificate › Recommended for general laboratory pipettes › Adheres to ISO 8655 Standard for data integrity 2. UKAS Calibration Certificate › Aligned with ISO/IEC 17025 standard for global recognition › Ensures compliance for regulated environments › All service options include comprehensive testing, inspection, cleaning, and documentation Benefits of UKAS Calibration › Recognised calibration certificates worldwide › Guaranteed traceability to national standards › Clear presentation of results and measurement uncertainty Understanding Uncertainty of Measurement › Lower uncertainty implies higher result quality › Sartorius’ accredited certificates display uncertainty clearly As Found Calibration › Shows pipette performance since last service › Crucial for GLP or GMP environments Calibration Levels Choose from six calibration levels, based on gravimetric weighings at different volumes. Options range from weighing at a single volume to three test volumes. Contact Alpha Laboratories For tailored solutions, connect with our experts to discuss your pipette service needs. Arrange service by specifying location, calibration level, and pipette details. Visit our dedicated website or email us for a personalised quote. Visit www.alphalabservice.co.uk or email pipette-service@alphalabs.co.uk for more information
12 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Fine Tip Pastette® For careful control and small volume transfers Fine Tip Pastette have a soft controllable bulb to provide high level control and function for quick and easy procedures. Minimal force is needed to aspirate and dispense the liquid, which is consistent across the full range of Pastette. Fine Tip Pastette are available in varied designs with alternative drop volumes, draw volumes and lengths to suit various tasks. Over the years, modified versions have been developed from the standard design to support customers with their application needs. These included extending the stem length to be able to reach into smaller vessels, a longer fine tip for the separation of supernatants, larger bulb volumes for filling ID strips and mini versions for small volume drop work, (which are popular) in the blood donation centres. One feature that does remain the same is the perfectly circular cross section tip, which provides precise control and accuracy of the drop volume when aspirating. Many applications will require small volumes of liquid to be transferred between a variety of different vessels. Fine Tip Pastette® are LDPE transfer or pasteur pipettes that are a simple solution and a safe alternative to glass pipettes. They are manufactured to the highest quality to ensure the best performance and accuracy for the user. SPECIAL OFFER SAVE 40%
13 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) LW4638 Extended Fine Tip Standard Sterile Bulb draw 3.5ml Drop Vol. 20µl 500 £58.84 £35.30 LW4232 Extended Fine Tip Sterile Bulb draw 3.3ml Drop Volume 20µl 500 £57.56 £34.54 LW4238 Extended Fine Tip Sterile Bulb draw 3.3ml Drop Volume 20µl - 400 x single wrap 400 £69.26 £41.56 LW4234 Fine Tip Maxi Non Sterile Bulb draw 4.8ml Drop Volume 22µl 400 £41.89 £25.13 LW4237 Extended Fine Tip Mini Sterile Bulb draw 1ml Drop Volume 20µl 500 £57.56 £34.54 LW4244 Extended Fine Tip Ultra Micro Non Sterile Bulb draw 1.0ml Drop Volume 22µl 500 £36.87 £22.12 Premium Quality Crafted from top-grade materials, these pipettes guarantee durability and reliability. Variety of Designs Making measurements a breeze for even the most varied tasks. Ease of Use The soft controllable bulb ensures a comfortable handling experience and accurate drop wise dispensing from the fine tip. Sterile and Non-Toxic Sterile options available to ensure a contamination-free environment for your critical work. Ideal for supernatant removal, slide preparation and gel loading: › Precise control › Careful aspiration › Great for use with test strips Specialist versions are available for specific applications: › Fine Tip Mini for colony picking › Fine Tip Maxi for sample removal › Extended Fine Tip for small drop work Pastette® Ordering Information Don’t compromise on quality, choose Pastette®. Order online at www.alphalabs.co.uk/finetip or Quote Offer Code LV2302 LW4638 LW4234 LW4237 LW4244 LW4232/LW4238 SPECIAL OFFER SAVE 40%
14 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Since the 1990’s the Nanoject from Drummond Scientific has been the pinnacle of microinjection, designed to perform ultra-delicate nanolitre injection procedures into oocytes, embryos, and tissues. The latest version, the Nanoject III, optimises sample injection efficiency to accurately deliver nanolitre volumes into both suspended and attached cells, while reducing associated cellular stress. Several features of the popular Nanoject II have been incorporated into the next generation Nanoject III. The same body design makes the Nanoject III compatible with most stereotaxic equipment. A high level of stability and precision are required in microinjection. This is crucial to minimise cellular stress and deliver the highest efficiency for improved cell/organism viability. The proven hydraulic technology of the Nanoject III ensures accurate and consistent injection, while the high torque motor significantly reduces tip movement, allowing finer manipulation. Glass micropipettes with an internal diameter of 10μm can be used with this model. The Nanoject III can be used for much lower volume injection using micropipettes with an internal diameter down to 2-3μm. Furthermore, the Nanoject III does not use any O-rings to secure the micropipette. Instead, a small chuck and silicone receiver have been incorporated, making insertion of the glass micropipette much easier. With the Nanoject III, the volume range has been expanded to 0.6nL-999.9nL, with a variable injection rate between 1nL/second200nL/second, compared to its predecessor which had a range of 2.3nL - 69nL. This capability not only extends the range of model organisms that can be investigated, but also allows investigation at multiple developmental stages using varying injection volumes. Nanoject III Programmable Nanolitre Injector Next Generation Nano Injection – High Performance, Ultra Delicate
15 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Programmable An injection counter has been incorporated in the Nanoject III together with multiple injection capability and programmable frequency of injections. This enables the user to set up multiple injection cycle recipes that can be automatically saved and labelled in sequential order. Up to 8 programs can be saved. Program input and execution is enabled by prompted touchscreens located on the control box. This makes frequently used injection protocols easy to call up and run. The Nanoject III Programmable Nanolitre Injector is supplied as a kit that contains: The control box & power source, Injector, Injector head cable, 3.5” glass capillaries - 100 pieces, 7” glass capillaries - 100 pieces, Backfilling needle and Universal adapter. Product Code Description List Price (excl. VAT) 3-000-207 Programmable Nanoject III Auto Injector £4,150.00 Nanoject III - Specifications Power Source 100/240 volt, 50/60 Hz Total Sample Volume 4.2 µL Fill / Empty Volume Speed 10 - 200 nL/sec Injection Volume Range 0.6 - 999.9 nL Injection Rate 1 - 200 nL/sec Plunger Travel 23 mm Glass Micropipette Dimensions OD 0.045˝ (1.14 mm), ID 0.021˝ (0.53 mm) Nanoject III Auto Injector Ordering Information To find out more information and buy online, please visit: www.alphalabs.co.uk/nanoject
16 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Intelligent Gene Amplification Technology Bioer GeneExplorer™ Collection – A thermal cycler model to suit all PCR needs SPECIAL OFFER SAVE £1000 GeneExplorer is our latest thermal cycler. It brings you optimal accuracy and versatility for qualitative gene amplification. Intelligent Operation › New generation of Central Processing Unit (CPU). › 8-inch responsive touch screen › User-friendly Advanced User Interface (UI) › Makes your operation simple and faster Temperature Accuracy › Newly designed block and tailor-made Peltier › Ensures stable and reliable thermal performance › Optimises your PCR temperature with good accuracy Mobile App Sync › Innovative mobile app synchronisation and Wi-Fi capability helps to monitor your PCR status with remote control Dual Block GeneExplorer › The dual-block GeneExplorer is the ideal thermal cycler when working with smaller sample sizes › Two 48-well format blocks allow for two different programs to run independently to provide maximum flexibility and versatility It’s like having two instruments in one! Choice of Options › 96 or 384 well gradient block or 48 dual block
17 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) GE-96G 96 well Bioer GeneExplorer™ Touchscreen Gradient thermal cycler Each £5,130.00 £4,130.00 GE-48D 48 well Dual Block Bioer GeneExplorer™ Touchscreen Gradient thermal cycler Each £5,239.08 £4,239.08 GE-384G 384 well Bioer GeneExplorer™ Touchscreen Gradient thermal cycler Each £5,400.00 £4,400.00 Bioer GeneExplorer™ Thermal Cycler Ordering Information To find out more information and buy online, please visit: www.alphalabs.co.uk/GeneExplorer Quote Offer Code LV2303 to save £1000 Remote Operation Interface on Mobile Phone App Program Screen Home Screen SPECIAL OFFER SAVE £1000
18 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) MB-102 ThermoCell heating, cooling & mixing base unit Each £1,578.42 £947.05 HB-202 ThermoCell heating base unit Each £599.72 £359.83 CHB-202 ThermoCell heating and cooling base unit Each £709.00 £425.40 ThermoCell System Ordering Information SPECIAL OFFER SAVE 40% SPECIAL OFFER SAVE 40% To find out more information and buy online, please visit: www.alphalabs.co.uk/ThermoCell or Quote Offer Code LV2304 SPECIAL OFFER SAVE 40% The ThermoCell System Heating? Cooling? Mixing? – or All Three? ThermoCell blocks from Bioer offer the combination of mixing and temperature control functions, providing a convenient means to incubate and react samples. The ThermoCell unit is ideal for sample preparation and cloning applications, enzyme preservation, catalytic reactions, and many other laboratory protocols. The range features: › Wide temperature setting range (0-105C) › Provides accurate, stable temperature control (≤±0.5C) › Lightweight and compact design for portability. › Sample block design is easily removed for cleaning or replacement › Large display and simple controls provide a userfriendly interface The ThermoCell range offers a choice of three models to best suit your needs: ThermoCell heating base unit (HB-202) ThermoCell heating block offers a low-cost solution for limited budgets where cooling is not required. ThermoCell heating and cooling base unit (CHB-202) ThermoCell Heating and cooling base unit efficiently heats or cools samples and thus is ideal for a variety of molecular biology and other laboratory procedures. ThermoCell heating cooling and mixing base unit (MB-102) The ThermoCell Mixing block combines the functions of mixing and precise temperature control, providing a convenient means to incubate and react samples.
19 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 SPECIAL OFFER HALF PRICE BLOCK* *when bought with ThermoCell unit Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) BLOCK A Block for 40 x 1.5ml tubes Each £233.60 £116.80 BLOCK B Block for 54 x 0.5ml tubes Each £249.97 £124.99 BLOCK C Block for 96 x 0.2ml tubes Each £249.97 £124.99 BLOCK D Block for 24 x 15mm tubes Each £249.97 £124.99 BLOCK E Water bath block Not for use with mixing block MB-102 Each £249.97 £124.99 BLOCK G Block for 26 x 0.5ml plus 24x 1.5ml tubes Each £274.49 £137.25 BLOCK H Block for 40 x 2.0ml tubes Each £249.97 £124.99 BLOCK J Block for an ELISA plate Each £263.97 £131.99 ThermoCell System Ordering Information Half price when purchased with your chosen ThermoCell unit, For more information or to buy, please visit: www.alphalabs.co.uk/ThermoCell Quote Offer Code LV2304 SPECIAL OFFER HALF PRICE BLOCK* ThermoCell Blocks These ThermoCell models are used with a selection of interchangeable blocks for various tube sizes ranging from 0.2ml to 15mm. A block is also available for use with ELISA-type 96-well plates. BLOCK B BLOCK C BLOCK D BLOCK E BLOCK G BLOCK J BLOCK H BLOCK A
20 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 PCR is one of the most commonly used techniques in molecular biology applications and undeniably a powerful analysis tool. However, avoiding contamination is key and this can sometimes be a challenge in multiuse/multipurpose laboratories. Create Your Dedicated PCR Workspace A dedicated clean area like the Mini PCR UV workstation can be a rewarding investment. Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) UV1000 Mini PCR Workstation with UV sterilisation Each £2,153.47 £1,700.00 EL2680 White General Purpose Tray 68x54cm whiter Each £95.26 £85.00 EL2670 Disposable APET liners 68 x 54cm for use with general purpose spill tray 25 £146.29 £115.00 PCR Workspace Bundle Ordering Information Create Your Complete PCR Workstation for only £1900! Offer includes Mini PCR UV Workstation with tray and liners. For a limited time only. Purchase yours now (Include all product codes in your order): www.alphalabs.co.uk and Quote Offer Code LV2305 BUNDLE OFFER ONLY £1900* › The UV light within the safety cabinet can be used to denature nucleic acids in 5-30 minutes rendering them unsuitable for amplification › Provides a clean set up area which can be lit with white light whilst working › The UV light is timer controlled and safety switches automatically turn it off if the doors are opened. This important safety feature prevents user exposure › The cabinet is designed to sit snuggly within a 68 x 54cm spill tray. › Disposable tray liners are also available Preparation for Perfect PCR Performance *Pipette and tube storage rack not included.
21 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Save over £70! To purchase your PCR Workstation Rack, visit: www.alphalabs.co.uk and Quote Offer Code LV2305 To complete your set up, you could include a dedicated PCR Worskstation Rack (LW5732AS) for just £170. These popular racks offer the perfect solution to PCR set-up whether you are using tubes, tube strips or plates. All are made from durable polypropylene and have sturdy lids. They are ideal for transporting samples and reactions between preparation, thermal cycling and postPCR procedure areas. They also come in a wide range of colours! The removable 96-Place Work-Up Rack holds commonly used plates, tubes or strip tubes. Complete Your PCR Set Up and Save Over £70 Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) LW5732AS PCR workstation rack with lid assorted colours 10 £243.00 £170.00 Workstation Rack Ordering Information Worskstation Rack (LW5732AS) - Specifications Dimensions: 170 × 110 × 105 mm, 78 mm without Lid Will hold: 32 x individual 0.2 ml tubes, 24 x 1.5 or 2.0 ml tubes or 16 x 0.5 ml tubes Ideal platform to satisfy all pre or post PCR sampling applications. Molded alphanumeric indexing for fast and accurate identification. Why not take advantage of the current discounts on Proline Plus® pipettes on page 9 to obtain a dedicated set of pipettes for your PCR work. Purchase now: www.alphalabs.co.uk/ProlinePlus and Quote Offer Code LV2301
22 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 When handling lots of different samples and reagents, colour-coding can be an ideal way to distinguish between them. Alpha Laboratories offers a range of colourful laboratory products to help you organise your storage and workspace. This will assist you with an efficient workflow, whether enabling easy identification of samples for different testing pathways, separate projects, different process steps or distinct reagents in your lab. Getting Organised Never Looked So Good Colour-Code Your Lab! A Great Way to Avoid Cross-contamination It’s not just samples and reagents that can benefit from colour coding. This can also be a great way to clearly identify a specific work area. The Drummond Pipet-Aids can be fitted with a coloured tissue culture nosepiece, ensuring easy-identification and your lab partners cannot steal your equipment without your knowledge! Find out more and buy online: www.alphalabs.co.uk/nosepiece Find out more and buy online: www.alphalabs.co.uk/ screw-caps Find out more and buy online: www.alphalabs.co.uk/ tethered Find out more and buy online: www.alphalabs.co.uk/ safegrip SafeGrip Screw Caps Tethered Screw Caps APEX® Standard Screw Caps APEX® Microcentrifuge Tube Caps Available in a multitude of colours, caps for the popular APEX screw cap tubes give you many options when it comes to organising your samples. Buy individual colours for different sample sets or our assorted selections containing a mix of 5 different colours. › Compatible with 0.5, 1.0 and 2.0ml APEX microcentrifuge tubes › Also available in a tethered version, making one-handed use much easier › ‘SafeGrip’ screw-caps in an attractive striped design provide a superior grip – ideal when you need to open tubes while wearing gloves!
23 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Product Code Product Description Pack Size List Price (excl. VAT) CP5940AS Flat Cap with O-Ring for Microcentrifuge Tube, Assorted Colours 500 £44.28 CP5950AS Tethered Flat Cap with O-Ring for Microcentrifuge Tube, Assorted Colours 500 £54.00 CP5960AS SafeGrip Flat Cap with Moulded Integral Seal for Microcentrifuge Tube, Assorted Colours 500 £44.28 LW3339AS Cap Insert Assorted colours for colour coding cryogenic vials 500 £18.36 4-000-079-Z Drummond Replacement Tissue Culture Nosepeice, Assorted Colours 6 £123.00 LW5220AS Rack 96-Position Reversible Combirack 12 x 8 Array Assorted Colours Fits 0.5ml 1.5ml and 2.0ml Microcentrifuge Tubes 5 £45.36 Colourful Laboratory Accessories Ordering Information Brighten up your lab today! www.alphalabs.co.uk Moving Into Cryogenic Storage? Easily identify your samples held in cryogenic storage with coloured cap inserts for our cryovials. These fit into the Classic, Feel the Seal, and Ultimate security ranges of cryogenic vials. Each cap insert has a small hole to enable removal if needed. Find out more and buy online: www.alphalabs.co.uk/cryogenic-cap-inserts Coordinate Your Tube Racks The 96-position reversible Combirack is compatible with 0.5ml microcentrifuge tubes on one side, with the reverse allowing storage of 96 x 1.5ml and 2.0ml microcentrifuge tubes › Available in 5 colours, for easily identifying your projects in a packed laboratory freezer › Can be autoclaved at up to 121C and is suitable for use in ultra-low temperature freezers (up to -90C) › Many other options are also available for everything up to 50ml centrifuge tubes Find out more and buy online: www.alphalabs.co.uk/combiracks
24 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 We all know that only high-quality consumables deliver optimal results in the Life Science laboratory. BRANDplates® pureGrade™ multi-purpose microplates, now available from Alpha Laboratories, are the perfect foundation for all your assays. This extensive range, compliant with ANSI/SLAS standards for automated systems, is manufactured under ISO class 7 cleanroom conditions, with automated packaging, to ensure the highest possible purity - even for non-sterilised assay plates. All plates are free from DNA, DNase RNase, and Pyrogens. pureGrade S plates are sterilised in accordance with ISO 11137 and AAMI standards. Multiple Microplates for Your Specific Applications Purity Without Compromise, Whatever the Grade Plate Sealing Solutions Whatever Your Application. Our easy sealing selector tool can help you find the perfect match. Excel Scientific provides expertise in plate sealing with specific features designed into their products to ensure perfect performance in your application. pureGrade™ Microplates for Every Occasion › Untreated hydrophobic surface to maximise sample recovery › Medium binding, suitable for ELISA applications › Crystal clear and UV options for optical measurements › 96 wells available in F, U, V and C well configurations Also available: › Black or white plates - solid or transparent bottom › 384 well or 1536 well plates for high-throughput applications › PCR › qPCR › Short-Term Storage / ELISA › Long-Term Storage › Cell Culture › Protein Crystallography › Luminescence / Fluorescence › HPLC Find out more: www.alphalabs.co.uk/ sealing-selector
25 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Product Code Product Description Pack Size List Price (excl. VAT) 781600 Microplate pureGrade™ 96-well, PS, standard transparent, 'U' bottom 330 µl, 100 pcs, 20 stacks of 5 plates 100 £134.95 781601 Microplate pureGrade™ 96-well, PS, standard transparent, 'V' bottom 360 µl, 100 pcs, 20 stacks of 5 plates 20x5 £105.00 781602 Microplate pureGrade™ 96-well, PS, standard transparent, 'F' bottom 350 µl, 100 pcs, 20 stacks of 5 plates 100 £134.95 781603 Microplate pureGrade™ 96-well, PS, standard transparent, 'C' bottom 350 µl, 100 pcs, 20 stacks of 5 plates 20x5 £105.00 781614 Microplate pureGrade™ 96-well, PS, 'F' bottom UV transparent, 350 µl, 50 pcs, 5 bags of 10 plates 10x5 £700.00 781660 Microplate pureGrade™ S 96-well, PS, sterile, standard transparent, 'U' bottom 330µl, 50pcs, packed in bags of 1 with lids 1x50 £135.00 781661 Microplate pureGrade™ S 96-well, PS, sterile, standard transparent,'V' bottom 360 µl, 50pcs, packed in bags of 1 with lids 1x50 £135.00 781662 Microplate pureGrade™ S 96-well, PS, sterile, standard transparent, 'F' bottom 350 µl, 50pcs, packed in bags of 1 with lids 1x50 £135.00 781663 Microplate pureGrade™ S 96-well, PS, sterile, standard transparent, 'C' bottom 350 µl, 50pcs, packed in bags of 1 with lids 1x50 £135.00 Microplates Ordering Information For more information and to buy please visit: www.alphalabs.co.uk/puregrade96
26 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 Exosomes, small extracellular vesicles (EV’s) ~40-100nm, are known to contain nucleic acids, proteins, lipids, amino acids, and/or metabolites, which can reflect their cell of origin and also their physiological function. They are known to be associated with a multitude of biological functions, such as immune responses, viral pathogenicity, pregnancy, cardiovascular diseases, cell signalling, CNS-related diseases, cancer progression, and more! Exosome research has become easier with the implementation of the second generation MagCapture™ isolation kit from FujiFilm Wako, which is far superior to conventional methods, delivering higher quality, intact exosomes. The MagCapture™ utilises the phosphatidylserine (PS) affinity binding which enables the elution of intact EV’s and exosomes. Support for Exosome Research PS-Affinity Binding Method T-cell immunoglobulin domain and mucin domain-containing protein 4 (Tim4), one of the receptors for EVs binds to phosphatidylserine, which is known to be expressed on the outer surface of exosome membranes, in a calcium iondependent manner. MagCapture V2 High-efficiency isolation/purification of exosomes is done by Tim4 immobilised on magnetic beads; the binding is released by Ca2+-chelating agents, such as EDTA. › Reaction time reduced from 3 hours to just 1 hour › Higher purity and improved recovery efficiency compared to conventional methods › Intact exosomes can be obtained › Reduced cytotoxicity and can be added directly to cells › Reproducible sample purification Other Exosome Research Products PS Capture™ Resin Kit Isolation kit for larger sample volumes (1.2mL – 40mL). Instead of magnetic bead (as in the MagCapture kits) this kit uses a non-magnetic resin to capture exosomes via PS affinity. Ultrafiltration of samples is unnecessary – purification by centrifugation only. PS Capture™ Exosome Flow Cytometry Kit Can detect any surface marker proteins on exosomes with high sensitivity by using fluorescent-labelled antibodies and flow cytometry after capturing EVs by PS Affinity Method. See illustration on next page. Elution Capture Tim4 Exosomes Magnetic beads EDTA Sample Preparation Beads Preparation (15 min) Affinity Reaction (60 min) Wash & Elution (35 min) Centrifugation Concentration (Option) Immobilization Biotin Capture Magnetic Beads Biotin - labeled Exosome Capture Reaction Tube Exosome Binding Enhancer Exosome Immobilizing / Washing Buffer + Exosome Binding Enhancer Exosome Elution Buffer
27 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 To find out more information and buy online, please visit: www.alphalabs.co.uk/Exosomes or Quote Offer Code LV2306 SPECIAL OFFER SAVE 10% ELISA Kits Five kits are available that either use PS-affinity to capture exosomes, or anti-CD9/-CD63/-CD-81 antibodies, compatible with human CD9, CD63 or CD81 proteins which are known to be expressed on the surface of human exosomes. A comparison chart is available for greater assessment of each kit. Complementary Research Products Magnet Stand Holds 16 x 1.5mL microtubes and can flip them in which traps magnetic beads against a magnet stand or flips them out for easy resuspension. EV-Save™ EV-Save™ Blocking Reagent protects extracellular vesicles (EVs) against freezing and suppresses their adsorption to labware such as test tubes and pipette tips. Also available for use in vivo – consists of ingredients successfully used as pharmaceutical additives. Cell Culture Media The medium is a set composed of the medium ‘EV-Up™ EV Production Basal Medium for MSC’ and its supplement ‘EV-Up™ MSC EV Production Supplement’ which enhances extracellular vesicles production from cells. Exosomes Metal ion (1) Exosome isolation (3) Flow cytometric analysis (2) Exosome staining Exosomes are isolated from a sample solution using Exosome Capture Beads. Flow cytometric analysis of magnetic beads with exosomes bound on the surface is performed. Exosomes are stained with a fluorescence-labeled exosome marker antibody Fluorescence-labeled exosome marker antibody Fluorescence intensity Counts 100 101 102 103 150 100 50 0 On capturing On stirring Magnet magnetic beads Exosome Capture 96 Well Plate HRP-conjugated Streptavidin Tim4 Exosome Antibody Biotinylated Product Code Product Description Pack Size List Price (excl. VAT) Offer Price (excl. VAT) MagCapture V2 290-84103 MagCapture™ Exosome Isolation Kit PS-Affinity Method V2 10 tests £1,450.00 £1,305.00 PS Capture™ Resin Kit 290-80301 PS Capture™ Exosome Isolation Resin Kit for large sample volumes 1 £1,225.00 £1,102.50 PS Capture™ Exosome Flow Cytometry Kit 297-79701 PS Capture™ Exosome Flow Cytometry Kit 300 tests £715.00 £643.50 ELISA Kits 290-83601 CD63-Capture Human Exosome ELISA Kit (Streptavidin HRP) 96 tests £1,900.00 £1,710.00 292-83801 CD81-Capture Human Exosome ELISA Kit (Streptavidin HRP) 96 tests £2,182.00 £1,963.80 296-83701 CD9-Capture Human Exosome ELISA Kit (Streptavidin HRP) 96 tests £2,182.00 £1,963.80 297-79201 PS Capture™ Exosome ELISA Kit Anti-Mouse IgG POD Tests for Exosome Analysis 96 tests £1,285.00 £1,156.50 298-80601 PS Capture™ Exosome ELISA Kit Streptavidin HRP Tests for Exosome Analysis 96 tests £1,225.00 £1,102.50 Magnet Stand 299-36421 Magnetic tube stand for capture of magnetic beads ideal for use with FUJIFILM Wako MagCapture Kits 1 £1,300.00 £1,170.00 EV-Save™ 050-09461 EV-Save™ Extracellular Vesicle Blocking Reagent for in vivo 1mL £355.00 £319.50 058-09261 EV-Save™ Extracellular Vesicle Blocking Reagent 1mL £285.00 £256.50 Cell Culture Media 053-09451 EV-Up™ EV Production Basal Medium for MSC's 95mL £329.00 £296.10 298-84001 EV-Up™ MSC EV Production Supplement 100mL £475.00 £427.50 052-09301 Purified exosomes from COLO201 cells 50µL 50µL £899.00 £809.10 Ordering Information
28 www.alphalabs.co.uk sales@alphalabs.co.uk 0800 387732 40 Parham Drive, Eastleigh, Hampshire, SO50 4NU, UK Tel: 023 8048 3000 | Email: sales@alphalabs.co.uk Web: www.alphalabs.co.uk Registered in England 1215816 All offers exclude existing contract agreements and apply to current list prices. Unless otherwise stated, offers described are valid until 31/12/23 or whilst stocks last. All other standard terms and conditions apply. Please enquire if further details are required. Offers are available online. When ordering by telephone, fax or email the relevant ‘LV’ code must be quoted to qualify for the discounted prices. Discounts cannot be applied retrospectively. Prices or offers may change without notice. Printed on Recycled Paper
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