Pricing and Online Ordering at www.alphalabs.co.uk Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk nemail order sales@alphalabs.co.uk nfreefax order 0800 614249 16 17 Quantitative Faecal Immunochemical Testing (FIT) Complete FIT Patient Packs The main two reagents are the latex reagent, and buffer solution. The latex reagent comprises of latex particles, coated in polyclonal antibodies specific to human haemoglobin. The high concentration of latex particle and antibody ensures a high antigen capture ratio. This provides four key benefits: n Low limit of detection: 1.25 µg Hb / g faeces n High hook (prozone) capacity: 200,000 µg Hb / g faeces n Linear assay range: 7 - 400 µg Hb / g faeces n Specific to human haemoglobin: no interference from dietary meat, supplements, or medication Reagents Sample Collection Device As with all assays, pre-analytical variation must be kept to a minimum, and that’s particularly challenging when patients are completing the sampling at home, and when the sample is from faeces. Faeces is rarely homogenous in nature, and the variability in composition can make sample collection challenging. The HM-JACKarc collection device is designed with easeof-use in mind, while ensuring good quality laboratory samples. The collection device is designed with two small dimples in the end of the sampling stick to allow the patient to accurately sample 2 mg of faeces with no laboratory experience or measuring equipment. The septum in the sample collection device scrapes off excess faecal matter, ensuring the 2 ml of buffer solution is accurately dosed with 2 mg of faeces. This offers a hygienic sampling method, which only involves collecting one faeces sample, and sampling the faeces once. The device contains a biocide to minimise the risk of haemoglobin degradation by the microbiome in the faeces, and the device is tested to a 95 kPa pressure differential: making the tube strong and leak-proof. Once the sample is collected, the collection device is stable for 14-days at room temperature, and 120-days at 2 - 8 C. The sample is pre-diluted (in a 1:1 ratio) and is ready to be loaded directly onto the analyser. The sample does not require any pre-analytical processing (dilution / filtration etc.) prior to loading. The analyser reports results in ng Hb per ml of buffer; since the HM-JACKarc uses a 1:1 dilution ratio, this can be directly converted (1:1) to µg Hb per gram for result reporting. The hygienic sampling device has helped increase the uptake of participation in bowel screening programmes; offering participants a straightforward test, which only involves one sampling process and includes a robust sampling stick, has increased the number of those returning the test, and so helped identify more earlystage cancers. Tamper evident seal and sample viewing window Rubber septum to remove excess sample Oval sample collection dimples Overlabel prevents contamination of the piercing area Complete FIT Patient Packs The convenience of patient sampling at home is one of the advantages of FIT. However, when setting up a FIT service we are often asked how best to facilitate getting the test to the patient, and how the patient returns the test to the laboratory. Alpha Laboratories has extensive experience in the area and we can help with bespoke Patient Packs. We can create a custom solution for your pathway which supports the GP, patient, and sample reception teams. Each service may be managed slightly differently; varying in the information provided to patients, the onward pathways, and the method of returning the sample. A bespoke instruction leaflet not only provides the patient with a clear, easy-to-follow guide to help them collect a good quality sample, but it can provide additional supporting information; such as links to “How-To” videos, QR-codes for additional information, or contact numbers for enquiries. The instruction leaflets have proved extremely beneficial for users. In a recent case study with the South West Cancer Alliance, their patient questionnaires highlighted that 95% of respondents found the instruction leaflet easy to understand, and 96% of respondents knew what to do with their test once complete. Getting a FIT Sample from Patient to Laboratory Customising your FIT service need not stop at a bespoke instruction leaflet. If your FIT service directly involves Primary Care (the patients are handed the sampling collection device while attending a GP consultation), your service will benefit from Alpha Laboratories’ Complete Patient Packs. The complete patient packs are bespoke to your service, and may contain: instruction leaflet, sample return envelope, test/laboratory request form, sample collection device, faeces collection aid (Fe-Col®), patient information sheets, and/or questionnaire cards – all packaged into a discrete envelope for the Primary Care provider to hand to patient for at-home sample collection. For further information, or to enquire about creating your own FIT packs, please visit: www.faecal-immunochemical-test.co.uk/patient-packs
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