Pricing and Online Ordering at www.alphalabs.co.uk Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk nemail order sales@alphalabs.co.uk nfreefax order 0800 614249 14 15 Quantitative Faecal Immunochemical Testing (FIT) Quantitative Faecal Immunochemical Testing (FIT) The faecal immunochemical test (FIT) is an established test for the quantification of haemoglobin in faeces. Faecal haemoglobin has been used as a biomarker for gastrointestinal disease for decades, primarily in colorectal cancer screening programmes, previously using qualitative, guaiac-based, faecal occult blood tests (gFOBT). In August 2023, the National Institute of Health and Care Excellence (NICE), published updated Diagnostic Guidance DG56 “Quantitative faecal immunochemical testing to guide referral for colorectal cancer pathway referral in primary care”. This recommends the use of FIT in primary care to guide referral for suspected colorectal cancer in patients who present with unexplained gastrointestinal symptoms, but do not meet the criteria for referral in the suspected cancer referral pathway. The Association of Coloproctology of Great Britain and Ireland and the British Society of Gastroenterology (BSG) also published guidelines in July 2022 for identifying patients requiring further bowel disease investigation. The recommendations emphasized FIT testing in primary care, the diagnostic accuracy of FIT for colorectal cancer with suspected cancer signs or symptoms, acceptability of FIT testing for symptomatic CRC in most circumstances, antidiscrimination at any stage of the diagnostic pathway and finally, the development of a programme to facilitate FIT implementation. Colonoscopy resource is overburdened, and many colonoscopies yield no pathology. Implementing FIT triages patients into secondary care, reserving resource for high risk patients or those presenting with red flag symptoms. FIT has proven not only to be an invaluable resource in the identification of colorectal cancer, but also for detection of pre-cancerous growths. Colorectal cancer is the fourth most common cancer in the UK and is highly treatable if identified early. FIT is now used in all UK nation’s Bowel Cancer Screening Programmes, and it is the test of choice in primary care referral pathways for colorectal cancer. Using a symptomatic cut-off of 10 µg Hb / g faeces, FIT can be used by clinicians to determine the ideal pathway for patients, quickly and reliably. It presents a cost-effective, easy to use, non-invasive test, which has helped improve the uptake of testing in screening and symptomatic cohorts, helping increase the value of the test in the pathway. The complete FIT solution provided by Alpha Laboratories Ltd, includes the HM-JACKarc platform which is recommended for use in the NICE DG56 guideline. A compact, bench-top system for rapid, automated testing of FIT samples, the HM-JACKarc is straightforward to use, low-maintenance, and features excellent low-end sensitivity (limit of detection: 1.25 µg Hb / g faeces) with a linear assay range of 7 – 400 µg Hb / g faeces. In conjunction with the user-friendly sampling device bespoke Patient Packs, and The Alpha Portal, the FIT solution offered by Alpha Laboratories provides a tailor-made package to support primary care, patients, laboratories, and clinicians throughout the entire pathway. For more information, case studies, and to view videos including discussions with experts in the field, please visit: www.faecal-immunochemical-test.co.uk FIT for All CLINICIAN LABORATORY PATIENT Quantitative Faecal Immunochemical Test (FIT) HM-JACKarc Analyser + Barcode reader Product code Description Pack Size 065787 HM-JACKarc II Analyser 1 unit 065553 EXTEL HEMO AUTO HS Latex 4 x 18ml 065556 EXTEL HEMO AUTO HS Calibrator 8 x 1ml 065557 EXTEL HEMO AUTO HS Control 8 x 1ml 065555 EXTEL HEMO AUTO Buffer 1 x 250ml 063631 EXTEL HEMO-AUTO MC Collection Picker 200 pieces 063632 EXTEL HEMO-AUTO MC Collection Picker 400 pieces 053150 HM-JACK Reaction Cell 1000 pieces 053151 HM-JACK Sample Cup 500 pieces 057848 HM-JACK Print Paper A 2 rolls 052404 Wash Liquid (Auto Detergent H) 1 x 200ml Canon Medical Diagnostics Ltd. The HM-JACKarc is a dedicated bench-top analyser which uses integrated spherical turbidimetry for the quantification of haemoglobin in faeces. The analyser is easy to use; a touchscreen, minimal menu depth, and password protection allows safe customisation of the system according to your pathway regardless of your cut-off. Up to 80 samples can be loaded at any one time, with a time to first result of 5.6 minutes, and subsequent results every 18-seconds, giving a throughput of 200 samples per hour. Being quick to set up and maintain, the analyser can be used in high-throughput screening settings or lower-throughput symptomatic testing. The assay has a linear range of 7 – 400 µg Hb / g faeces, a limit of detection of 1.25 µg Hb / g faeces, and no prozone effect to 200,000 µg Hb / g faeces. This provides assurance that the result is accurate: no patient is given an artificially low result while samples with a very low haemoglobin concentration will not be missed. HM-JACKarc Automated Faecal Immunochemical Testing System The automated quantitative Faecal Immunochemical Testing system from Canon Medical Diagnostics Ltd. integrates Analyser technology, with Reagent and Collection device (ARC), to provide a rapid and consistent, high throughput solution for both screening and symptomatic faecal immunochemical testing. The system comprises of three key components: the analyser, the reagents, and the sample collection device. n HM-JACKarc state-of-the-art automated analyser n Dedicated, sensitive, latex agglutination reagents nBespoke faecal sample tube Key features: n Limit of Detection: 1.25 µg Hb / g faeces n Limit of Quantitation: 7.00 µg Hb / g faeces n Linear assay range: 7 – 400 µg Hb / g faeces n No prozone effect up to 200,000 µg Hb / g faeces n High-speed performance: 200 samples / hour n Time to first result: 5.6 minutes 1. Load samples and reagents 2. Press START 3. First result in 5.6 minutes HM-JACKarc Analyser
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