Diagnostics for Digestive Health Management

Pricing and Online Ordering at www.alphalabs.co.uk Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk nemail order sales@alphalabs.co.uk nfreefax order 0800 614249 10 11 Calprotectin High Throughput Assay BÜHLMANN fPELA ® Assay BÜHLMANN fCAL® turbo fCAL® turbo Product code Description Pack Size* B-KCAL-RSET fCAL turbo reagents ~200 B-KCAL-CASET fCAL turbo calibrators 6 levels, 1ml each B-KCAL-CONSET fCAL turbo controls 3 x 2 levels, 1ml each B-CAL-EX3 Extraction buffer 3 x 125ml B-CAL-EX12 Extraction buffer 12 x 125ml BÜHLMANN Laboratories *Will vary depending on analyser Why Use BÜHLMANN fCAL® turbo? n Fastest calprotectin test with results in 10 minutes n Wide initial test range (20 - 2000 µg/g) keeps dilutions to a minimum n Optional automatic on-board dilution for samples >2000 µg/g to give reportable results up to 8000 µg/g n CALEX extraction device simplifies sample preparation and is loaded directly onto the analyser streamlining the workflow n Can be used with track systems in full random access mode n Sample preparation device, controls and calibrators are in stable, ready to use format n Excellent linearity across the assay range n Excellent correlation with other BÜHLMANN assays 0 250 500 750 1000 1250 1500 1750 2000 2250 0 250 500 750 1000 1250 1500 1750 2000 2250 Measured Mean (µg/g) Th. Conc (µg/g) Linear Dilution - Linearity plot performed with stool extract The BÜHLMANN fCAL® turbo is a quantitative random access calprotectin assay that combines speed, quality and flexibility. The wide assay range (20 - 8000µg/g) provides sensitivity at the low end for differentiation between IBS and IBD patients, whilst also giving an actual value to monitor IBD positive patients at the high end. With the ability to run on most standard clinical chemistry analysers (see www.alphalabs.co.uk/fcal-turbo for the most up to date list of analyser protocols available), there is no requirement for additional equipment saving expense on capital purchase, service contracts and valuable laboratory space. Products for Pancreatic Insufficiency BÜHLMANN fPELA ® Assay The BÜHLMANN fPELA ® assay for faecal pancreatic elastase utilises the same CALEX extraction device as the fCAL turbo assay, so it is possible to run both tests from a single extract. The fPELA assay is random access and runs on standard clinical chemistry analysers (Roche, Abbott, Beckman, Siemens etc) although there is also the BioSystems BA 200, a stand-alone solution as well. The assay is turbidimetric, with a dynamic range of 10 - 5000µg/g. Time to first result is 10 minutes with further results following every few seconds thereafter, making it one of the fastest faecal elastase assays available. Why use the BÜHLMANN fPELA Assay? n Utlilises the same CALEX extraction device as the fCAL turbo assay n Results available significantly quicker than the traditional ELISA assays n Random access testing on standard clinical chemistry analysers n Comparable results to the current ELISA based methods Data from historic NEQAS samples shows the BÜHLMANN fPELA gives comparable results to the current ELISA based methods: fPELA ® Assay Product code Description Pack Size B-KPELA-RSET fPELA turbo reagents ~100 tests* B-KPELA-CONSET fPELA turbo controls 3 x 1ml High and Low control B-KPELA-CASET fPELA turbo calibrators 6 x 1ml calibrators B-CALEX-C50 CALEX sample extraction device 50 tubes B-CALEX-C200 CALEX sample extraction device 200 tubes B-CALEX-C500 CALEX sample extraction device 500 tubes BÜHLMANN Laboratories *Will vary depending on analyser Pancreatic insufficiency is the reduction of production or transportation of the digestive enzymes which results in the inability to properly digest a meal (fats, proteins and carbohydrates). The insufficiency is not usually absolute, it is variable, which then has a graded impact on digestion and hence symptoms. Patients can suffer from a variety of gastric symptoms which can range in severity but include abdominal pain, weight loss, diarrhoea, smelly loose stools, flatulence, loss of appetite and fatigue – all of which can be confused with a variety of other gastric complaints; so performing a simple stool test to determine the level of elastase (a pancreatic enzyme) helps with the diagnosis of this condition – then clinicians just need to determine the cause...

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