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Neuroimmunology and Autoimmunity Neuroimmunology & Autoimmunity Autoantibodies to Glycoproteins and Glycolipids 314 Neuroimmunology and Autoimmunity Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk Immune-mediated neuropathies represent an important sub-section of peripheral neuropathies, particularly as they are progressive and may be treated successfully. Diagnostic testing for anti-ganglioside and/or anti-MAG antibodies plays a crucial role in the diagnosis and treatment of these diseases. Our neuroimmunology portfolio contains sensitive anti-ganglioside and specific anti-MAG antibody assays, in addition to an anti- Interferonb binding antibody assay. Guillain-Barré Syndrome (GBS) and related disease patterns constitute a group of demyelinating or axonal motor/ sensory neuropathies that are treatable. The demyelination of neurons by autoimmune processes directed against peripheral nerves can be triggered by infection of the upper air or gastrointestinal tracts (Campylobacter jejuni). Miller-Fisher Syndrome (MFS) is a variant of GBS with ophthalmoplegia, ataxia and areflexia. Similar to GBS, MFS may occur upon infection. More than 90% of patients have antibodies against ganglioside Q1b (GQ1b). Multifocal Motor Neuropathy (MMN) affects numerous, localised areas within a patient and is a progressive and chronic disease. In up to 80% of patients, serologic polyclonal antibodies against ganglioside M1 (GM1) may be found. These antibodies are known to be of pathologic relevance. The polyclonal neuropathies are distinguished from the monoclonal gammopathies, which originate from demyelinating neuropathies. As many as 10% of patients with a neuropathy of unknown etiology can be assigned to the group of monoclonal autoimmune processes. In as many as 50% of these patients, IgM antibodies against Myelin Associated Glycoprotein (MAG), a major component of the myelin sheath may be detected. Not only is the determination of anti-MAG antibodies of diagnostic significance, but it can also be important in the context of therapy (e.g. Rituximab). Polyneuropathies Disease Isotype Associated Autoantibodies Acute GBS > IgG GM1 AMAN1 > IgG GM1, GD1a AIDP2 > IgG GM1 AMSAN3 > IgG GM1 MFS and variants > IgG GQ1b, GD1b Chronic MAG4 neuropathy > IgM MAG5 CANOMAD6 > IgM GQ1b, GD1b Mononeuropathies MMN > IgM GM1 GA1, GM1 GM1, GM2 Key to table: 1AMAN = acute motor axonal neuropathy 2AIDP = acute inflammatory demyelinating polyneuropathy 3AMSAN = acute motor sensory axonal neuropathy 4MAG = Myelin-associated Glycoprotein 5MAG negative patients may be anti-SGPG positive and vice versa 6CANOMAD = chronic ataxic neuropathy ophthalmoplegia IgM agglutinins disyalosyl antibodies (such as GD1b and GQ1b)


Catalogue_WEB_WoP_Jun16
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