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Clinical Chemistry Hyaluronic Acid For the quantitative determination of Hyaluronic Acid (HA) in serum and plasma. HA is an unbranched glycosaminoglycan, composed of a single polymer chain of disaccharide units containing N-acetylhexosamine and hexose. Serum concentration of HA has been proven to be the most effective marker for assessing liver cirrhosis. HA can also be used, in conjunction with other markers, to accurately stage liver fibrosis. Immunoglobulins (A, G, M & D) Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk 240 n Dual liquid-stable reagent n Linearity: Up to 1000 ng/mL n Open-vial stability: 30 days when stored at 2-10C Technical information: HA in the sample combines specifically with HA-binding protein (HABP). Latex particles coated with anti-HABP antibody are then added to form an insoluble aggregate. The degree of turbidity of solution can be measured optically and is proportional to the concentration of HA in the sample. Hyaluronic Acid Catalogue Number Description Pack Size 992-71185 Hyaluronic Acid Reagent 2x15ml,2x6ml 993-71115 HA Calibrator Set 5x2ml 998-71165 HA Control Set 2x(2x2ml) Wako Chemicals 3-Hydroxybutyrate For the quantitative determination of 3-hydroxybutyrate (3-HB) ((also known as beta hydroxybutyrate)) in serum or plasma. Ketone bodies are produced from fatty acids in the liver. A build up of Ketones in the blood results in Ketosis which can progress to Ketoacidosis. Ketoacidosis is most common in individuals with uncontrolled Type I Diabetes but can occur in Type II Diabetes, during pregnancy. n Linearity for standard range: 3-1000μmol/L n Linearity for high sensitivity range: 0.2-200μmol/L n Reconstituted reagent stability: 3 weeks when stored at 2-8C Technical information: When a sample is mixed with R1, acetylacetate (AcAc) in the sample is broken down to acetone by acetoacetate decarboxylase (AADC). Upon addition of R2, 3-HB in the sample is oxidized in the presence of 3- Hydroxybutyrate dehydrogenase (3-HBDH) and thio-NAD. This oxidation triggers cyclic reactions. Since the original AcAc in the sample has been removed, only 3-HB is assayed by measuring the rate of Thio-NADH production spectrophotometrically. 3-Hydroxybutyrate Catalogue Number Description Pack Size 417-73501 3-hydroxybutyrate Reagent 1 2x27ml 413-73601 3-hydroxybutyrate Reagent 2 2x9ml 412-73791 Ketone Body Calibrator (3-HB: 300μmol/L) 4x5ml Wako Chemicals For quantification of immunoglobulin classes in human serum. The three main classes of immunoglobulins are A, G and M. Quantification of IgA, IgG and IgM may aid in the diagnosis of various immune disorders. More than one class of immunoglobulin is typically raised in patients with infections, inflammatory disorders, autoimmune disorders such as rheumatoid arthritis, systemic lupus erythematosus or scleroderma or hyperimmunisation reactions. A single class of immunoglobulin may be seen in patients with myeloma, chronic lymphocytic leukaemic and monoclonal gammopathy of undetermined significance. IgD is normally only present in trace amounts but measurement can be of use in the determination of IgD myelomas. n Range: 0-650 mg/dL IgA n Range: 0-2700 mg/dL IgG n Range: 0-500 mg/dL IgM n Range: 0-200 U/ml IgD Technical information: These are immunoturbidimetric assays. Formation of insoluble antigen-antibody complexes are accelerated and enhanced by the inclusion of polyethylene glycol in the reaction mix. The complex formation results in an increase in turbidity. Immunoglobulins Catalogue Number Description Pack Size A06621H Immunoglobulin A (IgA) Turbidimetric Assay 1x10;2x25ml A06607AH Immunoglobulin G (IgG) Turbidimetric Assay 1x10;2x25ml A06624H Immunoglobulin M (IgM) Turbidimetric Assay 1x10;2x25ml A00623H Immunoglobulin D (IgD) Turbidimetric Assay 1x10;2x25ml A00580 Protein Calibrator High 1x1ml A00701 Protein Calibrator Low 1x1ml A00590 Protein Control 1x1ml A08591 Protein Control Low 1x1ml A05746 IgD Calibrator 1x0.5ml Dialab Clinical Chemistry - H/I


Catalogue_WEB_WoP_Jun16
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