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Clinical Chemistry Haemoglobin A1c Quantitative immunoturbidimetric latex determination of A1c (HbA1c) in blood. The determination of HbA1c in whole blood together with glucose determination is used for monitoring the glycemic state of patients with diabetes mellitus. High levels of HbA1c may be a risk factor for further complications such as retinopathies. Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk 238 n Dual reagent system n Reconstituted reagent stable for 30 days when stored at 2-8C n HbA1c range: 2.0% - 16.0% Technical information: The sample is first mixed with latex solution which has the same non-specific absorption rate for both total haemoglobin and HbA1c. Subsequent addition of the antibody solution then leads to formation of a complex between the mouse anti-human HbA1c monoclonal antibody and HbA1c absorbed onto the latex particles. The goat anti-mouse IgG polyclonal antibody then causes agglutination and increased turbidity. The increase in turbidity is proportional to the amount of HbA1c in the sample absorbed onto the latex directly determining the %HbA1c. Haemoglobin A1c Catalogue Number Description Pack Size 17418 Haemoglobin A1c Calibrator Set 4x0.5ml 17419 Haemoglobin A1c Control Set 2x(2x0.5)ml Sentinel See page 33 for more HbA1c Controls Haemoglobin (Total) For quantification of total haemoglobin in whole blood on photometric analysers. Total haemoglobin can be used to indicate how much oxygen is being carried by the red blood cells and in the diagnosis and monitoring of red blood cell disorders such as iron deficiency anaemia. n Colorimetric cyanmethaemoglobin end-point method n Whole blood with EDTA/Oxalate/Citrate/Heparin anticoagulant n Linearity: up to 20g/dl Technical information: Under alkaline conditions potassium ferricyanide oxidises haemoglobin and its derivatives to give methaemoglobin. This subsequently reacts with potassium cyanide to produce the stable, molecule, cyanmethaemoglobin. Colour intensity of the cyanmethaemoglobin at 540nm is proportional to the total haemoglobin in the patient sample. Total Haemoglobin Catalogue Number Description Pack Size Y04701 Total Haemoglobin Reagent 5x50ml Y04705SV Haemoglobin Calibrator 1x2ml Y04706 Haemoglobin Control Set 6x2ml Dialab Haptoglobin For the determination of haptoglobin in serum. Increased levels of Haptoglobin, a transport molecule for haemoglobin, are associated with inflammation, collagenoses, coronary disorders, Hodgkin’s disease, nephrotic syndrome and tuberculosis. Decreased levels are found in haemolytic anaemia, liver disease, congenital deficiencies and acute malaria. n Dual liquid-stable reagents n Measurable range: 0-500 mg/dL n Open-vial stability: until expiry date when stored at 2-8C Haptoglobin Catalogue Number Description Pack Size A00532 Haptoglobin Turbidimetric Assay - Antibody Reagent - PEG Buffer 1x10ml 5x25ml A00704 Protein Calibrator 5x1ml A00800 Protein Control 1x5ml Dialab Homocysteine For quantitative determination of total homocysteine in serum and plasma. Homocysteine is a by-product of methionine metabolism. Low quantities of homocysteine are not harmful to the body but excessive quantities can accumulate in the blood stream and may damage arterial vessels resulting in inflammation. This in turn can progress to artery disease and eventual blockage of the vessels leading to the heart. Measurement of homocysteine may be used as a risk factor for cardiovascular disease. n Ready to use reagents n Calibrators included n Open Vial Stability: 30 days n Linearity: up to 46µmol/L Technical information: Bound or dimerised homocysteine is reduced to free homocysteine which then reacts with serine, catalysed by cystathionine beta-synthase to form cystathionine. The cystathionine is then broken down in turn by cystathionine beta-lyase to give homocysteine, pyruvate and ammonia. The resulting pyruvate is then converted to lactate by lactate dehydrogenase with simultaneous oxidation of coenzyme NADH. The rate of NADH oxidation as measured at 340nm is directly proportional to the concentration of homocysteine. Homocysteine Catalogue Number Description Pack Size 17370H Homocysteine Liquid Kit 1x30ml;1x5ml 16370S Homocysteine Controls 3x(1x1.5)ml Sentinel Clinical Chemistry - H


Catalogue_WEB_WoP_Jun16
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