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Clinical Chemistry Calprotectin – a marker for inflammatory disease Calprotectin: the protein Calprotectin is a heterodimeric calcium binding protein (MRP8/14), which is present in both neutrophils and monocytes. Calprotectin is released from these cell types at sites of active inflammation. It is present in both plasma and faeces, but at 6-fold greater concentrations in the latter. In addition to calprotectin being a highly sensitive and specific marker for gut inflammation, it is also highly stable in faecal samples (up to 7 days when kept at 4C), making this protein a very practical biomarker. Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk 228 Application Overview Calprotectin allows for non-invasive differentiation between Inflammatory Bowel Diseases (IBD) and Irritable Bowel Syndrome (IBS). Calprotectin is a proven biomarker for IBD, such as Ulcerative Colitis (UC) and Crohn’s Disease (CD), when levels are raised in faecal samples. Cases of IBD require further investigation by colonoscopy, drug treatment regimes and can potentially be the precursor to fatal intestinal cancers. IBS (functional disease) does not have an inflammatory component and can be treated by changes in lifestyle and diet. Typically, IBS does not require colonoscopy and/or treatment regimes. A calprotectin assay differentiates between IBD and IBS in patients who present with gastrointestinal symptoms (e.g. abdominal pain, constipation). Calprotectin is markedly elevated in inflammatory diseases, but low in functional diseases or normal subjects. Elevated serum and plasma concentrations of MRP8/14 have recently been shown to play an important role in the management of patients suffering from cardio-vascular pathologies. Calprotectin Testing Alpha Laboratories has extensive experience in calprotectin testing and supplies a variety of test formats for its measurement depending on sample type, result format required (i.e. qualitative or quantitative) and sample throughput. The different options available are detailed below. We also offer a range of solutions to aid faecal sample collection, storage and extraction ready for testing - please see pages 267 - 269 or visit our website for further information. Clinical Chemistry - Calprotectin


Catalogue_WEB_WoP_Jun16
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