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Clinical Chemistry Ammonia For the enzymatic determination of ammonia in plasma. Ammonia is converted to urea in the liver hepatocytes and so rendered non-toxic. Excess ammonia can have a toxic effect on the central nervous system and clinical manifestations are typically neurological disturbances. Elevated ammonia concentrations may also occur in severe liver failure, resulting from Reye’s Syndrome, viral hepatitis or cirrhosis. n Linearity: up to 1700 μg/dL n Open-vial stability: 90 days when stored at 2-8C n Includes standard Alpha-1-Antitrypsin Pricing and Online Ordering at www.alphalabs.co.uk n freephone order 0800 387732 n buy online at www.alphalabs.co.uk 224 Alpha-2-Macroglobulin (Turbidimetric) For the quantitative immunoturbidimetric determination of Alpha 2-Macroglobulin in serum and plasma. Alpha 2-Macroglobulin is used as a marker of membrane permeability and is a plasma proteinase inhibitor. Increases in the level of Alpha 2-Macroglobulin occur in various pathological conditions such as nephrotic syndromes, hormonal dysfunctions, or disorders in child development. Decreased levels of this protein may be found during inflammatory processes, pancreatitis and prostatic carcinoma. n Dual buffer with antibody preparation n Measuring range: 70-1500 mg/dL n Open-vial stability: 60 days when stored at 2-8C Technical information: The determination is based on a turbidimetric reaction between a specific polyclonal antiserum and Alpha 2-Macroglobulin in the presence of polyethylenglycol polymer (PEG). The change in absorbance caused by the immuno-complex is proportional to the concentration of the analyte in the sample. Alpha 2-Macroglobulin (Turbidimetric) Catalogue Number Description Pack Size 11018D Alpha 2-Macroglobulin Turbidimetric Reagent 2x50ml,2x1ml,1x10ml 11200D Plasmaproteins Calibrator 3x1ml 11211A Immuno Control Set (2 Levels) 2x(2x1)ml Sentinel Technical information: Ammonia, in the presence of glutamate dehydrogenase (GLDH), combines with ketoglutarate and NADH to yield glutamate and NAD+. The decrease in absorbance (NADH ---> NAD+) at 340 nm is proportional to the ammonia concentration. The reagent contains lactate dehydrogenase (LDH) in excess, to rapidly reduce endogenous pyruvate so that it does not interfere with the assay system. Ammonia Catalogue Number Description Pack Size 17660 Ammonia Ultra Chemistry Reagent 3x20ml 16635 Ammonia Controls (Tri-level) 3x(1x5)ml Sentinel Amylase Enzymatic colorimetric determination of α-amylase according to IFCC recommendations in serum, plasma and urine. Amylases are hydrolytic enzymes that break down starch into maltose. Amylase assays can aid diagnosis of diseases such as chronic pancreatitis and the inflammatory phase of acute pancreatitis. Hyperamylasemia can be associated with renal failure, pulmonary or salivary gland disease and cerebral trauma. To confirm pancreatic specificity, it is recommended that another pancreas specific enzyme be determined. n Dual liquid-stable reagent n Linearity: up to 1500 U/L n On-board stability is typically 14 days Technical information: Amylase catalyses the hydrolysis of the EPS substrate (Ethylidene Protected Substrate) p-nitrophenyl-maltoheptaoside 4,6-ethylidene-blocked (ethylidene- G7PNP) forming 2 ethylidene-G5 + 2 G2PNP + 2 ethylidene-G4+ 2 G3PNP + ethylidene-G3 + G4PNP. The -glucosidase hydrolyses all fragments of G2PNP, G3PNP and G4PNP into p-nitrophenol (PNP) and glucose (G). The increase of absorbance, due to PNP formation, is proportional to the activity of α-amylase in the examined sample. Amylase Catalogue Number Description Pack Size 17632H Amylase Colorimetric Reagent 1x65ml;1x18ml 16550 Clin Chem Calibrator 4x3ml 16150 Clin Chem Control 1 6x5ml 16250 Clin Chem Control 1 6x5ml Sentinel For the quantitative immunoturbidimetric determination of alpha-1- antitrypsin in serum or plasma. Increased levels of alpha-1-antitrypsin may occur in inflammatory processes (infectious and rheumatoid diseases), tissue necrosis, traumas and inflammation of the liver parenchymal cells. In cases of neonatal hepatitis hereditary alpha-1-antitrypsin deficiency may be suspected. n Dual liquid-stable reagent n Measuring range 45-900 mg/dL n Open-vial stability: 120 days at 2-8C Technical information: The method is based upon the specific reaction between the alpha-1- antitrypsin polyclonal antibody and target antigen in the presence of polyethylenglycol polymer at optimal pH. The turbidity resulting from the immunocomplex is proportional to the concentration of Alpha-1-antitrypsin in the sample. Alpha-1-Antitrypsin Catalogue Number Description Pack Size 11012N Alpha-1-Antitrypsin Turbidimetric Reagent 2x50ml;2x1ml 11200D Plasmaproteins Calibrator 3x1ml 11211A Immuno Control Set (2 Levels) 2x(2x1)ml Sentinel Clinical Chemistry - A


Catalogue_WEB_WoP_Jun16
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